Gastrointestinal (GI): NSAIDs that block COX-1 exercise have correlations with GI complications due to inhibition in the synthesis of gastroprotective agents for example PGE2 along with other prostaglandins. This inhibition contributes to diminished mucin creation by gastric epithelial cells, less bicarbonate secretion, and less epithelial cell turnover, among other actions. https://michaele275uci9.gigswiki.com/user